Priv.-Doz. Dr. Claudia Manzl

The underlying molecular mechanisms of neurodegenerative diseases and brain tumors are still not fully explored or understood. My primary scientific interest lies in elucidating the cellular processes involved in the development and progression of gliomas. In my research, I particularly focus on the role of iron metabolism in the brain and its impact on the onset and progression of neuronal tumors (e.g., glioblastoma) and neurodegenerative diseases like Alzheimer’s, in collaboration with Dr. Anna Birkl-Töglhofer (PI). I combine in vitro models with innovative molecular and imaging techniques to better understand the processes that lead to disease and how they are regulated at the cellular and molecular level. A key focus of my work is the application of various sequencing techniques and quantitative imaging to precisely investigate tumor dynamics and microstructural changes in the brain.

In addition to basic research on the mechanistic aspects of gliomas and Alzheimer’s, I am also active in clinical research and am deeply involved in the molecular analysis of patient samples. An important part of my work is the development and implementation of molecular diagnostic techniques to enable early detection and accurate classification of brain tumors and neurodegenerative diseases. These molecular diagnostic tools are crucial for improving patient care, as they allow for individualized treatment planning.

My goal is to deepen the understanding of the molecular mechanisms in neuro-oncology and neuropathology through the integration of innovative technologies and interdisciplinary approaches, thus contributing to the development of new diagnostic tools and therapeutic strategies.