Anna Maria Birkl-Tögglhofer, PhD

My research focuses on the detailed exploration of molecular and cellular mechanisms that drive the development and progression of neurodegenerative diseases and brain tumors. A particular emphasis of my work is on the study of iron metabolism in the brain and its role in diseases such as Alzheimer’s and gliomas. In close collaboration with PD Dr. Claudia Manzl, I investigate how disruptions in iron homeostasis contribute to disease development and the molecular processes that occur at the cellular level.

A central aspect of my work involves using advanced in vivo models and brain tissue analysis to gain deeper insights into the mechanisms behind disease development. In particular, through collaboration with the Department of Radiology, I utilize quantitative imaging techniques to non-invasively map iron distribution and structural changes in the brain at various stages of disease. This integrated approach allows me to expand our understanding of how the absence or dysregulation of iron in the brain promotes the onset of neurodegenerative processes and tumor development.

Another key element of my research is the application of Nanopore sequencing technology in brain tumor research. This cutting-edge technology allows for the detailed analysis of the genetic and epigenetic profiles of gliomas and provides real-time long-term sequencing data. Through this technology, new perspectives on tumor heterogeneity and evolution are revealed, offering potential therapeutic targets for intervention.

In addition, I am actively involved in the development of a brain tissue bank that facilitates the systematic collection, processing, and storage of post-mortem human brain tissue. This valuable resource will not only provide high-quality, thoroughly characterized samples for molecular, histological, and imaging studies, but will also include detailed clinical data. The brain tissue bank serves as an essential foundation for collaborative research projects and will significantly advance our understanding of disease mechanisms in the brain. Through my research, I aim to identify new biomolecular markers that enable more precise diagnostics and personalized treatment strategies. My work, in close collaboration with interdisciplinary teams, and the application of innovative technologies, opens up new perspectives for understanding neurodegenerative diseases and brain tumors, providing valuable insights for clinical research.